ok just got my Ruger back and bought a box of .45 lc. that's probably a better home defense round than the .454s i had it loaded with
If you can shoot .45 LC - .45 Long Colt Shotshells are available, possibly a reload with the plastic shotshell insert with #4 buck would fill the bill...
To be honest for home defense, I would not even think about reaching for my pistol, I have several Remington 870’s filled with #4 buck low-power 24-28 pellets I loaded for this use.
Late at night I want a longer gun I can use that is simple and intimidating, I can hold it with both hands, and in a pinch would make a good club...

- you just can’t beat a shotgun 20,12,16 or other at pistol ranges... even with “low power” loads it is what it is...
I ordered the new Lee 00 buckshot mould that will pour 18 pellets at one time - I scrounge lead at the range (with a sieve and a shovel we can get over 50 pounds of lead in about 10 min of sifting) and that is free lead for pellets, bullets (pre-mixed for hardness), bullet cores and slugs...